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In addition, MDD diagnosis includes somatic effects, such as disturbances in food intake weight loss or gainin sleep insomnia or hypersomniaas well as in levels of psychomotor activity agitation or retardation. Based on this evidence, the authors argue that the mPFC D1 system regulates temporal control of goal-directed behavior, rather than the encoding of passage of time. Similarly, following chronic unpredictable mild stress, chronic vmPFC DBS reduced depression-associated anhedonia, as assessed by a sucrose preference test in rats and relieved from social avoidance in mice susceptible to chronic social defeat stress Hamani et al. Ventromedial prefrontal cortex pyramidal cells have a temporal dynamic role in recall and extinction of cocaine-associated memory. Working memory performance, alertness and temporal control Working memory is a complex brain process that refers to temporary storage of information time scale of seconds to minutes necessary for cognitive performance Baddeley,

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Changes in oscillation synchrony are also thought to underlie other psychiatric conditions, including bipolar disorder and autism, as well as epilepsy Uhlhaas and Singer, ; Sheline et al.

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Hillsborough survivor whose two daughters were crushed to death at match tells manslaughter trial he Optogenetic inhibition of dmPFC pyramidal neurons also attenuated stress-induced reinstatement of palatable food seeking in rats Calu et al. Back to top Home News U. Optogenetic modulation revealed that colossally projecting cells differentially innervate both subtypes and showed that PV interneurons preferentially inhibit subcortically projecting pyramidal neurons Lee et al. Furthermore, most long-range excitatory inputs are severed in acute slices, hindering measurements with electrical stimulation. In addition, depending on the behavioral read-out e. Taken together, over the years both clinical and preclinical research implicated the mPFC as a crucial mediator of depressive symptomatology Koenigs and Grafman,which triggered a quest for causality and a clarification of the exact contributions of mPFC subregions and their distinct afferent and efferent projections in the development of the disorder and antidepressant response.

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